Yuzhou Cai , Ying Ye , Jingxian Qian. Public Health. 2025 May:242:340-351
This study aimed to assess global, regional, and national trends in breast cancer burden attributable to high body mass index (BMI) from 1990 to 2021 and provide projections up to 2036 using data from the Global Burden of Disease...
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Early-onset cancer (EOC), occurring in individuals aged 15-49 years, is a growing global health concern. High body mass index (BMI) is an established modifiable risk factor contributing to cancer morbidity and mortality. In 2021,...
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Xiaoru Feng, Ruoqian Li, and Hang Yi. Obesity. 2025 Mar;33(3):567-577
The objective of this study was to estimate cancer burden attributable to excess body weight (EBW) and identify its main source. The incidence of 11 EBW-related cancers has increased from 1990 to 2021. Later-born cohorts and older...
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Colorectal cancer (CRC) remains a leading global malignancy with a rising obesity-attributable burden. Emerging evidence highlights concerning trends in early-onset CRC and marked regional disparities, underscoring the need for co...
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Chen Wang, Mengxi Du, Hanseul Kim, et al. JAMA Oncol. 2026 Jan 1;12(1):49-57
In this study, higher UPF intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of UPFs in early-onset colorectal tumorigenesis and support improving die...
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Hao Dai; Yongqiu Li; Yao An Lee; et al. JAMA Oncol. Published online August 21, 2025
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely prescribed for glycemic control in type 2 diabetes and have recently gained popularity for weight management. We compared the incidence of 14 cancers among adults wit...
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Lindsey Wang, Rong Xu, David C Kaelber et al. JAMA Netw Open 2024;7;(7):e2421305
Thirteen human malignant neoplasms have been identified as obesity-associated cancers (OACs), ie, the presence of excess body fat is associated with increased risk of developing cancer and worse prognosis in patients with these sp...
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Xianhua Mao, Xinrong Zhang, Linda Henry, et al. JNCI: J. National Cancer Institute, 117:10, October 2025, 2053-2061
Among 919, 609 overweight or obese individuals with type 2 diabetes, 16 653 newly diagnosed with obesity-related cancer were recorded during the 2, 086 ,526 person-years of follow-up. GLP-1 agonist users (vs other glucose-lowering...
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Darren R. Brenner; Yibing Ruan; Chantelle Carbonell. JAMA Network Open. 2025;8(9):e2530904
Excess body size has emerged as an impactful component of population-level cancer risk. Current data suggest that at least 13 cancer sites are convincingly associated with excess body size, most often characterized by a body mass...
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Ze Cong, Oth Tran, James Nelson,et al. Health Economics and Health Policy (2022) 20:845–856
The total economic burden of cancer reflects direct and indirect costs, including productivity loss due to employment change, absenteeism, and presenteeism of patients and caregivers. During the first year after diagnosis, compare...
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Simiao Chen; Zhong Cao; Klaus Prettner; et al. JAMA Oncol. 2023;9(4):465-472
Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries’ economicgrowth. This study estimated and projected the economic cost o...
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The increasing incidence of early-onset colorectal cancer (age <50 years; EOCRC) shows a dramatic growing trend globally, while late-onset colorectal cancer (LOCRC) is gradually decreasing. Between Jan 1 and Dec 31, 2024, 17 13...
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