Articles

Identification of Patients at Elevated Cancer Risk through a community‑based genetic testing program

Danielle Brabender, Emily Siegel, Julie O. Culver, et al. Ann Surg Oncol (2025) 32:9041–9049

Only a subset of individuals meeting National Comprehensive Cancer Network (NCCN) guidelines for genetic screening of hereditary cancers are being offered testing. A total of 14,192 women were screened, with 3224 (23%) meeting NCCN criteria. Of these patients, 50.3% opted for testing and 7.6% were found to have P/LP v... Read More

24 Mar, 2026

Germline Genetic Testing After Cancer Diagnosis

Allison W Kurian, Paul Abrahamse, Allison Furgal, et al. JAMA. 2023 Jul 3;330(1):43-51

Germline genetic testing is recommended by practice guidelines for patients diagnosed with cancer to enable genetically targeted treatment and identify relatives who may benefit from personalized cancer screening and prevention. Among 1 369 602 patients diagnosed with cancer between 2013 and 2019 in California and Geor... Read More

24 Mar, 2026

The financial toxicity of cancer: unveiling global burden and risk factors – a systematic review and meta-­ analysis

Tegene Kitaw. Befkad Tilahun, Alemu Zemariam, et al. BMJ Glob Health 2025;10:e017133.

Cancer, a major global health challenge, not only threatens lives but also imposes severe financial burdens, known as ‘financial toxicity’. This strain extends beyond treatment costs to include indirect expenses like lost income and out-­ of-­ pocket payments. Despite its urgency, global insights remain fragmented, oft... Read More

24 Mar, 2026

Working, Low Income, and Cancer Caregiving: Financial and Mental Health Impacts

Cathy J Bradley, Sara Kitchen, Kelsey M Owsley . J Clin Oncol. 2023 Jun 1;41(16):2939-2948

Approximately 6 million people provide caregiving to people diagnosed with cancer. Many must remain employed to support their household and to have access to health insurance. It is unknown if caregiving for a spouse diagnosed with cancer is associated with greater financial and mental stress relative to providing care... Read More

24 Mar, 2026

Cost of cancer management by stage at diagnosis among Medicare beneficiaries

Sheila R. Reddy, Michael S. Broder, Eunice Chang et al. Current Medical Research and Opinion. Volume 38, Pages 1285-1294 2022

We used 2012–2016 data from the Surveillance, Epidemiology, and End Results (SEER) registry-Medicare claims database to examine cost of care among Medicare beneficiaries with a confirmed cancer diagnosis. From 2012 to 2016, we identified 597,778 Medicare beneficiaries with incident cancer diagnosis within 5 years (Stag... Read More

24 Mar, 2026

Increased healthcare costs by later stage cancer diagnosis

November McGarvey, Matthew Gitlin, Ela Fadli,and Karen C. Chung. BMC Health Services Research (2022) 22:1155

Cancer represents a significant source of disease burden in the United States (US), both clinically and economically. Diagnosis and treatment of cancer at earlier stages may reduce this burden. To better understand potential impacts of earlier diagnosis, healthcare costs among patients with cancer were assessed by canc... Read More

24 Mar, 2026

Productivity Loss and Indirect Costs for Patients Newly Diagnosed with Early versus Late Stage Cancer in the USA

Ze Cong, Oth Tran, James Nelson,et al. Health Economics and Health Policy (2022) 20:845–856

The total economic burden of cancer reflects direct and indirect costs, including productivity loss due to employment change, absenteeism, and presenteeism of patients and caregivers. During the first year after diagnosis, compared to patients without metastases, significantly higher proportions of patients with metast... Read More

24 Mar, 2026

Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050

Simiao Chen; Zhong Cao; Klaus Prettner; et al. JAMA Oncol. 2023;9(4):465-472

Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries’ economicgrowth. This study estimated and projected the economic cost of 29 cancers in 204 countries and territories. The estimated global economic cost of cance... Read More

24 Mar, 2026

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study

Jinming Li, Yedong Pan, Fanying Guo. Lancet Oncol.. 2025 Aug;26(8):1055-1066

The increasing incidence of early-onset colorectal cancer (age <50 years; EOCRC) shows a dramatic growing trend globally, while late-onset colorectal cancer (LOCRC) is gradually decreasing. Between Jan 1 and Dec 31, 2024, 17 133 tumor samples from patients with colorectal cancer in eight countries were analyzed. In ... Read More

24 Mar, 2026

Early-Onset Gastrointestinal Cancers: A Review

Thejus Jayakrishnan, Kimmie Ng. JAMA. 2025 Oct 21;334(15):1373-1385

Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US. Worldwide, among early-onset GI cancers rep... Read More

24 Mar, 2026