Articles

Productivity Loss and Indirect Costs for Patients Newly Diagnosed with Early versus Late Stage Cancer in the USA

Ze Cong, Oth Tran, James Nelson,et al. Health Economics and Health Policy (2022) 20:845–856

The total economic burden of cancer reflects direct and indirect costs, including productivity loss due to employment change, absenteeism, and presenteeism of patients and caregivers. During the first year after diagnosis, compared to patients without metastases, significantly higher proportions of patients with metast... Read More

24 Mar, 2026

Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050

Simiao Chen; Zhong Cao; Klaus Prettner; et al. JAMA Oncol. 2023;9(4):465-472

Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries’ economicgrowth. This study estimated and projected the economic cost of 29 cancers in 204 countries and territories. The estimated global economic cost of cance... Read More

24 Mar, 2026

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study

Jinming Li, Yedong Pan, Fanying Guo. Lancet Oncol.. 2025 Aug;26(8):1055-1066

The increasing incidence of early-onset colorectal cancer (age <50 years; EOCRC) shows a dramatic growing trend globally, while late-onset colorectal cancer (LOCRC) is gradually decreasing. Between Jan 1 and Dec 31, 2024, 17 133 tumor samples from patients with colorectal cancer in eight countries were analyzed. In ... Read More

24 Mar, 2026

Early-Onset Gastrointestinal Cancers: A Review

Thejus Jayakrishnan, Kimmie Ng. JAMA. 2025 Oct 21;334(15):1373-1385

Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US. Worldwide, among early-onset GI cancers rep... Read More

24 Mar, 2026

Global cancer statistics of young adults and its changes in the past decade: Incidence and mortality from GLOBOCAN 2022

Jian Li, Xiaohong Kuang. Public Health 237 (2024) 336–343

This study aimed to assess the disease burden of cancer in young adults globally and the changes between 2012 and 2022. In young adults, 47.22 % of new cases were breast, thyroid and cervical cancer, while the leading causes of cancer-related death were breast, leukemia and cervical cancer. Compared to 2012, the nu... Read More

24 Mar, 2026

The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990-2019: a secondary analysis for the global burden of disease study 2019

Jiao Su, Yuanhao Liang, Xiaofeng He, et al. Front Nutr. 2024 May 31:11:1384352

Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of early-onset CRC attributable to dietary risks remain unclear. This study aimed to estimate the burden of early-onset CRC attributable to dietary risk factors globally, regionally, and nation... Read More

24 Mar, 2026

Increase of early-onset colorectal cancer: a cohort effect

Laura Downham, Mathieu Laversanne , Sandra Perdomo, et al JNCI: Journal of the National Cancer Institute, 2025, 00(00), 1–6

Increasing incidence rates of early-onset colorectal cancer (ie, <50years of age) have been reported across multiple countries. We investigated long-term cancer incidence data from 1995 or earlier from Australia, Canada, England, and the United States separately by sex. All countries showed increasing early-onse... Read More

24 Mar, 2026

Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data

Hyuna Sung, Rebecca L Siegel, Mathieu Laversanne, et al. Lancet Oncol 2025; 26: 51–63. 2025

Previous studies have shown that colorectal cancer incidence is increasing among younger adults (aged <50 years) in multiple high-income western countries in contrast with stabilizing or decreasing trends in incidence in older adults (aged ≥50 years). In the most recent 5 years (2013–17 for all countries analyse... Read More

24 Mar, 2026

Age-specific trends in colorectal, appendiceal, and anal tumor incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis

Aaron L. Meyers, James G. Dowty, Khalid Mahmood, et al. The Lancet Regional Health – Western Pacific 2025;64

Early-onset bowel cancer incidence (age <50 years) has increased worldwide. Combining all malignant tumor histologies, early-onset incidence rose 5–9% annually, yielding 4072 excess cases (1⋅5 per 100,000 person-years; 15% appendix, 28% colon, 48% rectum, 9% anus). Trends varied by site, period, and age: appendi... Read More

24 Mar, 2026

The global burden of breast cancer among women of reproductive age: a comprehensive analysis

Yuzhou Cai, Fangyi Dai, Ying Ye, et al. Sci Rep. 2025 Mar 18;15(1):9347

Breast cancer is the most prevalent malignant disease among women and affects women of reproductive age (15-49 years) across the globe. This study examines patterns and trends in the epidemiology of breast cancer in women of reproductive age using global burden of disease data (1990-2021), with the objective of in... Read More

24 Mar, 2026