There has been a concerning 79.1% global rise in incidence between 1990 and 2019 of early onset cancer (EOC), defined as cancers diagnosed under age 50. EOC diagnoses now account for 12% of all cancer diagnoses. The largest increa...
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S. Daniel Haldar, Amanda Huff, Hejia Henry, et al.
Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a minority of precursors. Mutant KRAS (mKRAS)...
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Rami James N Aoun and Matthew F Kalady. Surg Oncol. 2022 Aug: 43:101765
Approximately 5% of colorectal cancers arise within an inherited colorectal cancer syndrome, with known underlying genetic etiologies. These syndromes increase the risk of colorectal and extracolonic cancers. Identification of a s...
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Breast cancer is the most common cancer in women globally with enormous associated morbidity, mortality and economic impact. Prevention of breast cancer is a global public health imperative. To date, most of our global efforts hav...
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Danielle Brabender, Emily Siegel, Julie O. Culver, et al. Ann Surg Oncol (2025) 32:9041–9049
Only a subset of individuals meeting National Comprehensive Cancer Network (NCCN) guidelines for genetic screening of hereditary cancers are being offered testing. A total of 14,192 women were screened, with 3224 (23%) meeting NCC...
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Isabelle A. Lucas Beckett, Kate R. Emery, Josiah T. Wagner. npj Genomic Medicine | (2025) 10:50
Genomic medicine is now at a point where increased sequencing speed, cost reduction, and scalable cloud platforms can enable population-scale clinical sequencing. As 88% of US hospitals are community hospitals, integrating genomic...
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Thejus Jayakrishnan, Kimmie Ng. JAMA. 2025 Oct 21;334(15):1373-1385
Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most ra...
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