Chunling Hu, Steven N Hart, Rohan Gnanaolivu et al. N Engl J Med. 2021 Feb 4;384(5):440-451
In a population-based case-control study, we performed sequencing using a custom multigene amplicon-based panel to identify germline pathogenic variants in 28 cancer-predisposition genes among 32,247 women with breast cancer (case...
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Xia Wei, Samuel Oxley, Ranjit Manchanda et al. Cancers 2022, 14, 6117
This systematic review found that surgical prevention is cost-effective for women in high-income countries who are at a high risk of breast cancer, intermediate/high risk of ovarian cancer and high risk of endometrial cancer. Synt...
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Abdosaleh Jafari, Fatemeh A Hosseini, Faride S Jalali et al.Health Sci Rep. 2024 Aug 21;7(8):e70002
Colorectal cancer is the third most common cancer in the Western Hemisphere. It is the third most common cancer in men after prostate and lung cancers and the second most common cancer in women after breast cancer. The data from 3...
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Divya Rao , Chloe Wernecke, Lisa Baron, et al. Breast J. 2026 Jan 19:2026:8670441
The Tyrer-Cuzick (TC) or IBIS risk calculator is a widely used tool to estimate the probability of developing breast cancer. The TC is commonly used to guide patients toward further diagnostic imaging, genetic testing, chemopreven...
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Breast cancer is the most common cancer in women globally with enormous associated morbidity, mortality and economic impact. Prevention of breast cancer is a global public health imperative. To date, most of our global efforts hav...
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Angela N Giaquinto , Hyuna Sung , Lisa A Newman , et al CA Cancer J Clin. 2024 Nov-Dec;74(6):477-495
Breast cancer incidence continued an upward trend, rising by 1% annually during 2012-2021, largely confined to localized-stage and hormone receptor-positive disease. A steeper increase in women younger than 50 years (1.4% annually...
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Tingting Wei , Yunhai Li , Ze Zhang , et al. Eur J Surg Oncol. 2026 Mar 7;52(5):111742
Women's cancers pose a significant global health burden, with pronounced geographical and age-related disparities. Targeting modifiable risk factors and enhancing healthcare access, especially in low-SDI regions, is essential to r...
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S. Ogino and T. Ugai. Annals of Oncol;.35(12) 1071-1073. 2024
The incidence of early-onset cancer (EOC) diagnosed in individuals under the age of 50 has been increasing worldwide, which may be just the tip of the iceberg of larger emerging issues, including the rise of various chronic diseas...
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In recent years, the incidence of early-onset cancers among individuals under 50 years of age has been on the rise. From 1990 to 2021, the incidence rate of all early-onset cancers in China increased by 150.72 per 100,000, while t...
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Kevin Chiu, Joanna P MacEwan, Suepattra G May, et al. MDM Policy Pract. 2022 Aug 3;7(2)
Cancer can have a profound impact on productivity. Traditional approaches to capturing health-related productivity loss focus only on the foregone wages of affected patients, overlooking the losses caregivers can incur. This study...
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Ana N Ehsan, Catherine A Wu, Alexandra Minasian, et al. JAMA Netw Open. 2023 Feb 1;6(2):e2255388
Financial toxicity (FT) is the negative impact of cost of care on financial well-being. Patients with breast cancer are at risk for incurring high out-of-pocket costs given the long-term need for multidisciplinary care and expensi...
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Cancer imposes a substantial economic burden on patients that may be worse in patients with higher-stage disease due to the need for more therapy. The cohort consisted of 46,158 patients (mean age at diagnosis, 46 years; 30,...
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