November McGarvey, Matthew Gitlin, Ela Fadli,and Karen C. Chung. BMC Health Services Research (2022) 22:1155
Cancer represents a significant source of disease burden in the United States (US), both clinically and economically. Diagnosis and treatment of cancer at earlier stages may reduce this burden. To better understand potential impac...
Read More
Presently, colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. We provided global, regional, and national estimates of the burden of CRC and their attributable risks from 1990 to 2021, aiming to...
Read More
Lindsey Wang, Rong Xu, David C Kaelber et al. JAMA Netw Open 2024;7;(7):e2421305
Thirteen human malignant neoplasms have been identified as obesity-associated cancers (OACs), ie, the presence of excess body fat is associated with increased risk of developing cancer and worse prognosis in patients with these sp...
Read More
Chen Wang, Mengxi Du, Hanseul Kim, et al. JAMA Oncol. 2026 Jan 1;12(1):49-57
In this study, higher UPF intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of UPFs in early-onset colorectal tumorigenesis and support improving die...
Read More
Colorectal cancer (CRC) remains a leading global malignancy with a rising obesity-attributable burden. Emerging evidence highlights concerning trends in early-onset CRC and marked regional disparities, underscoring the need for co...
Read More
Xiaoru Feng, Ruoqian Li, and Hang Yi. Obesity. 2025 Mar;33(3):567-577
The objective of this study was to estimate cancer burden attributable to excess body weight (EBW) and identify its main source. The incidence of 11 EBW-related cancers has increased from 1990 to 2021. Later-born cohorts and older...
Read More
Qiuxia Zhang , Jia Feng , Zhijie Xu, et al. Public Health. 2025 May:242:388-398
A strong association between high Body Mass Index (BMI) and Colorectal Cancer (CRC) has been well established. This study aims to examine and analyze the burden of CRC linked to high BMI at global, regional, and national levels fr...
Read More
Pedro Nascimento de Lima , Lillian Bartholomew , Folasade P May, et al. J Natl Cancer Inst. 2026 Feb 1;118(2):360-363
Colorectal cancer (CRC) screening accounts for over 60% of cancer screening costs in the United States, prompting recurrent debates about its value. Yet CRC screening remains the main tool to curb overall CRC incidence, mortality,...
Read More
Jianjiu Chen, and Wan Yang. JNCI Cancer Spectrum, 2024, 8(4), pkae052
Incidence of early-onset colorectal cancer (CRC) has increased globally in recent decades. We examined early-onset CRC incidence trends worldwide for potential cohort effects, defined as changes associated with time of birth (eg,...
Read More
Takahisa Matsuda, Ai Fujimoto, Yoshinori Igarashi . Digestion. 2025;106(2):91-99
Colorectal cancer (CRC) is a significant global health issue, ranking as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths. Countries with a high Human Development Index (HDI) report th...
Read More
C. Santucci, S. Mignozzi, M. Malvezzi, et al. Ann Oncol. 2024 Mar;35(3):308-316
We predicted cancer mortality figures for 2024 for the European Union (EU), its five most populous countries, and the UK. We predicted cancer mortality figures for 2024 for the European Union (EU), its five most populous countries...
Read More
Allison W Kurian, Paul Abrahamse, Allison Furgal, et al. JAMA. 2023 Jul 3;330(1):43-51
Germline genetic testing is recommended by practice guidelines for patients diagnosed with cancer to enable genetically targeted treatment and identify relatives who may benefit from personalized cancer screening and prevention. A...
Read More