Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, et al.
The incidence of early-onset cancers, commonly defined as cancers diagnosed before age 50 years, has been increasing globally over recent decades. In particular, the incidence of several early-onset digestive system cancers, inclu...
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Xin Yang, Juliet A Usher-Smith, Kristina M Blackmore, et al.
Risk-based breast cancer (BC) screening can provide tailored recommendations based on individual risk. We estimated 10-year BC risks in 3753 women aged 40-70 with no cancer history. The primary endpoint was risk reclassification,...
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Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, et al.
This nationwide observational study investigated recent trends in pancreatic cancer (PC) incidence and surgical management in Japan. Over the study period, the annual average PC incidence was 43 015, and the average number of PC s...
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S. Daniel Haldar, Amanda Huff, Hejia Henry, et al.
Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a minority of precursors. Mutant KRAS (mKRAS)...
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Silvia Mignozzi, Claudia Santucci, Gianfranco Alicandro, et al. Cancer Causes Control. 2026 Apr 3;37(5):79
An increasing cancer incidence has been observed among recent generations over the last decade. However, apart from colorectal cancer, these increases were not associated with rises in mortality. We extracted death counts for indi...
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Agnes Brandtmüller , Anne Meiwald , Peter Toth , et al. J Med Econ 2026 Dec;29(1):785-798
Cancer imposes a substantial clinical and economic burden across Europe. This analysis estimated the lost productivity cost of the five cancer types with the highest premature mortality and five cancer types with the highest morbi...
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Allison W Kurian, Paul Abrahamse, Allison Furgal, et al. JAMA. 2023 Jul 3;330(1):43-51
Germline genetic testing is recommended by practice guidelines for patients diagnosed with cancer to enable genetically targeted treatment and identify relatives who may benefit from personalized cancer screening and prevention. A...
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C. Santucci, S. Mignozzi, M. Malvezzi, et al. Ann Oncol. 2024 Mar;35(3):308-316
We predicted cancer mortality figures for 2024 for the European Union (EU), its five most populous countries, and the UK. We predicted cancer mortality figures for 2024 for the European Union (EU), its five most populous countries...
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Gisella Figlioli , Daniele Piovani , Andreas G Tsantes et al. Clinical Nutrition 48 (2025) 144e152
High body mass index (BMI) is a well-established cancer risk factor. Reliable, updated data are essential for guiding public health policies and designing effective interventions to reduce the cancer burden associated with high BM...
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Lindsey Wang, Rong Xu, David C Kaelber et al. JAMA Netw Open 2024;7;(7):e2421305
Thirteen human malignant neoplasms have been identified as obesity-associated cancers (OACs), ie, the presence of excess body fat is associated with increased risk of developing cancer and worse prognosis in patients with these sp...
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Thejus Jayakrishnan, Kimmie Ng. JAMA. 2025 Oct 21;334(15):1373-1385
Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most ra...
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Silvia Mignozzi, Claudia Santucci, Fabio Levi, et al. Eur J Cancer Prev. 2026 Mar 1;35(2):97-107.
We provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cuba, and Mexico), focusing on prostate cancer. We extracted mortality data for all cancers combine...
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