Shuai Xu, Sara Murtagh, Yunan Han,et al. JAMA Netw Open. 2024 Jan 2;7(1):e2353331
Breast cancer in young women has a less favorable prognosis compared with older women. This cross-sectional study used data from Surveillance, Epidemiology, and End Results 17 registries (2000-2019). Women aged 20 to 49 years with a primary invasive breast cancer were included. Out of 217 815 eligible women, the majority were diagnosed with an ER+/PR+ tumor (134 024 [61.5%]) and were diagnosed with a stage I tumor (81 793 [37.6%]). Overall, invasive breast cancer incidence increased (AAPC, 0.79) with increasing trends across almost all racial and ethnic groups. ASIR increased for ER+/PR+ (AAPC, 2.72) and ER+/PR- tumors (AAPC, 1.43), and decreased for ER-/PR+ (AAPC, -3.25) and ER-/PR- tumors (AAPC, -0.55). For women aged 20 to 29 and 30 to 39 years, ASIRs were highest among non-Hispanic Black women (age 20-29 years: IRR, 1.53; age 30-39 years: IRR, 1.15). For women aged 40 to 49 years, ASIR was lower for non-Hispanic Black women (IRR, 0.96) compared with non-Hispanic White women. Incidence rates increased for stages I and IV tumors but decreased for stage II and III tumors. Age-period-cohort analysis demonstrated both cohort and period effects on breast cancer incidence (P < .001). In this population-based cross-sectional analysis, an increase in breast cancer incidence rates among young US women and age-related crossover between non-Hispanic White and Black women were observed. Prevention efforts in young women need to adopt a targeted approach to address racial disparities in incidence rates observed at different age phases.
12 May, 2026